Inhibition of mucus secretion by niclosamide and benzbromarone in airways and intestine

URN to cite this document:: urn:nbn:de:bvb:355-epub-553400
DOI to cite this document:: 10.5283/epub.55340

Ousingsawat, Jiraporn

; Centeio, Raquel ; Reyne, Nicole ; McCarron, Alexandra ; Cmielewski, Patricia ; Schreiber, Rainer

; diStefano, Gabriella ; Römermann, Dorothee ; Seidler, Ursula ; Donnelley, Martin ; Kunzelmann, Karl

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 18 Jan 2024 05:19

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Abstract

The Ca2+ activated Cl− channel TMEM16A (anoctamin 1; ANO1) is expressed in secretory epithelial cells of airways and intestine. Previous studies provided evidence for a role of ANO1 in mucus secretion. In the present study we investigated the effects of the two ANO1-inhibitors niclosamide (Niclo) and benzbromarone (Benz) in vitro and in vivo in mouse models for cystic fibrosis (CF) and asthma. In ...