Subcellular localization of PD‐L1 and cell‐cycle‐dependent expression of nuclear PD‐L1 variants: implications for head and neck cancer cell functions and therapeutic efficacy

URN to cite this document:: urn:nbn:de:bvb:355-epub-553763
DOI to cite this document:: 10.5283/epub.55376

Schulz, Daniela

; Feulner, Laura ; Rubenich, Dominique S.

; Heimer, Sina ; Rohrmüller, Sophia ; Reinders, Yvonne ; Falchetti, Marcelo ; Wetzel, Martin ; Braganhol, Elizandra

; Lummertz da Rocha, Edroaldo ; Schäfer, Nicole ; Stöckl, Sabine ; Brockhoff, Gero

; Wege, Anja K.

; Fritsch, Jürgen

; Pohl, Fabian ; Reichert, Torsten E. ; Ettl, Tobias

; Bauer, Richard J.

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Date of publication of this fulltext: 23 Jan 2024 07:00

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Abstract

The programmed cell death 1 ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) axis is primarily associated with immunosuppression in cytotoxic T lymphocytes (CTLs). However, mounting evidence is supporting the thesis that PD-L1 not only functions as a ligand but mediates additional cellular functions in tumor cells. Moreover, it has been demonstrated that PD-L1 is not exclusively localized ...