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Subcellular localization of PD‐L1 and cell‐cycle‐dependent expression of nuclear PD‐L1 variants: implications for head and neck cancer cell functions and therapeutic efficacy

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Schulz, Daniela ; Feulner, Laura ; Rubenich, Dominique S. ; Heimer, Sina ; Rohrmüller, Sophia ; Reinders, Yvonne ; Falchetti, Marcelo ; Wetzel, Martin ; Braganhol, Elizandra ; Lummertz da Rocha, Edroaldo ; Schäfer, Nicole ; Stöckl, Sabine ; Brockhoff, Gero ; Wege, Anja K. ; Fritsch, Jürgen ; Pohl, Fabian ; Reichert, Torsten E. ; Ettl, Tobias ; Bauer, Richard J.
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Date of publication of this fulltext: 23 Jan 2024 07:00


The programmed cell death 1 ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) axis is primarily associated with immunosuppression in cytotoxic T lymphocytes (CTLs). However, mounting evidence is supporting the thesis that PD-L1 not only functions as a ligand but mediates additional cellular functions in tumor cells. Moreover, it has been demonstrated that PD-L1 is not exclusively localized ...


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