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Increased PD-L1 expression in radioresistant HNSCC cell lines after irradiation affects cell proliferation due to inactivation of GSK-3beta

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Schulz, Daniela ; Stancev, Irene ; Sorrentino, Antonio ; Menevse, Ayse N. ; Beckhove, Philipp ; Brockhoff, Gero ; Hautmann, Matthias G. ; Reichert, Torsten E. ; Bauer, Richard J. ; Ettl, Tobias
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Date of publication of this fulltext: 23 Jan 2024 08:54


At present, targeting PD-1/PD-L1 axis for immune checkpoint inhibition has improved treatment of various tumor entities, including head and neck squamous cell carcinoma (HNSCC). However, one part of the patient cohort still shows little improvement or even hyperprogression. We established three radioresistant (RR) and three radiosensitive (RS) HNSCC cell lines. RR cells showed prolonged survival ...


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