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Recirculating IL-1R2+ Tregs fine-tune intrathymic Treg development under inflammatory conditions

Nikolouli, Eirini ; Elfaki, Yassin ; Herppich, Susanne ; Schelmbauer, Carsten ; Delacher, Michael ; Falk, Christine ; Mufazalov, Ilgiz A. ; Waisman, Ari ; Feuerer, Markus ; Huehn, Jochen


The vast majority of Foxp3(+) regulatory T cells (Tregs) are generated in the thymus, and several factors, such as cytokines and unique thymic antigen-presenting cells, are known to contribute to the development of these thymus-derived Tregs (tTregs). Here, we report the existence of a specific subset of Foxp3(+) Tregs within the thymus that is characterized by the expression of IL-1R2, which is ...


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