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CaMKIIδ Met281/282 oxidation is not required for recovery of calcium transients during acidosis

Kreitmeier, K. G. ; Tarnowski, D. ; Nanadikar, M. S. ; Baier, M. J. ; Wagner, S. ; Katschinski, D. M. ; Maier, L. S. ; Sag, C. M.



Abstract

CaMKII is needed for the recovery of Ca2+ transients during acidosis but also mediates postacidic arrhythmias. CaMKIIS can sustain its activity following Met281/282 oxidation. Increasing cytosolic Na+ during acidosis as well as postacidic pH normalization should result in prooxidant conditions within the cell favoring oxidative CaMKII delta activation. We tested whether CaMKII delta activation ...

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