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TMEM16A Mediates Mucus Production in Human Airway Epithelial Cells

Cabrita, Inês ; Benedetto, Roberta ; Wanitchakool, Podchanart ; Lerias, Joana ; Centeio, Raquel ; Ousingsawat, Jiraporn ; Schreiber, Rainer ; Kunzelmann, Karl



Abstract

TMEM16A is a Ca2+-activated chloride channel that was shown to enhance production and secretion of mucus in inflamed airways. It is, however, not clear whether TMEM16A directly supports mucus production, or whether mucin and TMEM16A are upregulated independently during inflammatory airway diseases such as asthma and cystic fibrosis (CF). We examined this question using BCi-NS1 cells, a human ...

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