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The role of HIF-1α in nicotine-induced root and bone resorption during orthodontic tooth movement

Ullrich, Niklas ; Schröder, Agnes ; Bauer, Maria ; Spanier, Gerrit ; Jantsch, Jonathan ; Deschner, James ; Proff, Peter ; Kirschneck, Christian


Background: In orthodontic tooth movement (OTM), pseudo-inflammatory processes occur that are similar to those of nicotine-induced periodontitis. Previous studies have shown that nicotine accelerates OTM, but induces periodontal bone loss and dental root resorption via synergistically increased osteoclastogenesis.This study aimed to investigate the role of hypoxia-inducible factor 1 alpha (HIF-1 ...


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