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Sleep-disordered breathing is independently associated with reduced atrial connexin 43 expression

Hegner, Philipp ; Lebek, Simon ; Tafelmeier, Maria ; Camboni, Daniele ; Schopka, Simon ; Schmid, Christof ; Maier, Lars Siegfried ; Arzt, Michael ; Wagner, Stefan


BACKGROUND Patients with atrial fibrillation (AF) exhibit decreased atrial expression of connexin (Cx), which has been causally linked to a proarrhythmogenic substrate. Interestingly, patients with sleep-disordered breathing (SDB) are at increased risk of AF, but the mechanisms remain unclear. OBJECTIVE We tested the hypothesis that patients with SDB have reduced atrial Cx expression independent ...


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