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Complement Factor H-Related 3 Enhanced Inflammation and Complement Activation in Human RPE Cells

Schäfer, Nicole ; Rasras, Anas ; Ormenisan, Delia M. ; Amslinger, Sabine ; Enzmann, Volker ; Jägle, Herbert ; Pauly, Diana


Complement Factor H-Related 3 (FHR-3) is a major regulator of the complement system, which is associated with different diseases, such as age-related macular degeneration (AMD). However, the non-canonical local, cellular functions of FHR-3 remained poorly understood. Here, we report that FHR-3 bound to oxidative stress epitopes and competed with FH for interaction. Furthermore, FHR-3 was ...


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