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Single-cell microRNA sequencing method comparison and application to cell lines and circulating lung tumor cells

Hücker, Sarah M. ; Fehlmann, Tobias ; Werno, Christian ; Weidele, Kathrin ; Lüke, Florian ; Schlenska-Lange, Anke ; Klein, Christoph A. ; Keller, Andreas ; Kirsch, Stefan


Molecular single cell analyses provide insights into physiological and pathological processes. Here, in a stepwise approach, we first evaluate 19 protocols for single cell small RNA sequencing on MCF7 cells spiked with 1pg of 1,006 miRNAs. Second, we analyze MCF7 single cell equivalents of the eight best protocols. Third, we sequence single cells from eight different cell lines and 67 circulating ...


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