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Chimäre Antigenrezeptoren (CAR) – universelle Werkzeuge in der zellulären Immuntherapie

Holzinger, A. ; Abken, H.


Background The observation that tumor-infiltrating lymphocytes (TIL) after ex vivo amplification can control tumors in the long term led to the concept of redirecting patients cytolytic T-cells by a receptor with defined specificity against the tumor. Objectives Development of a recombinant receptor-signal molecule (chimeric antigen receptor, CAR) to increase selectivity and enhance anti-tumor ...


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