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Allele-specific expression of GATA2 due to epigenetic dysregulation in CEBPA double-mutant AML

Mulet-Lazaro, Roger ; van Herk, Stanley ; Erpelinck, Claudia ; Bindels, Eric ; Sanders, Mathijs A. ; Vermeulen, Carlo ; Renkens, Ivo ; Valk, Peter ; Melnick, Ari M. ; de Ridder, Jeroen ; Rehli, Michael ; Gebhard, Claudia ; Delwel, Ruud ; Wouters, Bas J.


Transcriptional deregulation is a central event in the development of acute myeloid leukemia (AML). To identify potential disturbances in gene regulation, we conducted an unbiased screen of allele-specific expression (ASE) in 209 AML cases. The gene encoding GATA-binding protein 2 (GATA2) displayed ASE more often than any other myeloid- or cancer-related gene. GATA2 ASE was strongly associated ...


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