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Whole blood-based in vitro culture reveals diminished secretion of pro-inflammatory cytokines and chemokines in visceral leishmaniasis

Tasew, Geremew ; Gadisa, Endalamaw ; Abera, Adugna ; Chanyalew, Menberework ; Abebe, Markos ; Howe, Rawleigh ; Ritter, Uwe ; Aseffa, Abraham ; Laskay, Tamás


The likelihood of being bitten by sand flies infected with Leishmania (L.) donovani is considered to be high for all inhabitants living in the endemic areas, but only a small ratio of the population develop symptomatic visceral leishmanisis (VL). Since adequate activation of antimicrobial immune response plays a key role in control of pathogens early after infection we hypothesized that a ...


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