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CAR-T-Zellen als Arzneimittel für neuartige Therapien (Advanced Therapy Medicinal Products)

Köhl, Ulrike ; Abken, Hinrich


Background Two commercial chimeric antigen receptor (CAR) T cell products, axicabtagene-ciloleucel (Yescarta (R)) and tisagenlecleucel (Kymriah (R)), are registered for the treatment of B cell neoplasia, for which an increased supply of CAR T cell products is required. Problem The production of patient-specific CAR T cells as advanced therapy medicinal products (ATMPs) poses considerable ...


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