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Persistent urothelial differentiation changes in the reconstructed exstrophic bladder: Congenital or acquired dysfunction of the epithelial barrier?

Rubenwolf, Peter ; Eder, Fabian ; Götz, Stefanie ; Promm, Martin ; Rösch, Wolfgang H.


Background We have previously characterised the urothelium from infants with classic bladder exstrophy (CBE) for the expression of urothelial differentiation associated markers. We found abnormal expression patterns of uroplakin 3a, cytokeratin 13, cytokeratin 20 and claudin 4 in the majority of bladder biopsies taken at the time of primary bladder closure. Abnormal urothelial differentiation ...


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