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Pals1 prevents Rac1-dependent colorectal cancer cell metastasis by inhibiting Arf6

Lüttgenau, Simona Mareike ; Emming, Christin ; Wagner, Thomas ; Harms, Julia ; Guske, Justine ; Weber, Katrin ; Neugebauer, Ute ; Schröter, Rita ; Panichkina, Olga ; Pethő, Zoltán ; Weber, Florian ; Schwab, Albrecht ; Wege, Anja Kathrin ; Nedvetsky, Pavel ; Krahn, Michael P.


Loss of apical-basal polarity and downregulation of cell-cell contacts is a critical step during the pathogenesis of cancer. Both processes are regulated by the scaffolding protein Pals1, however, it is unclear whether the expression of Pals1 is affected in cancer cells and whether Pals1 is implicated in the pathogenesis of the disease. Using mRNA expression data and immunostainings of cancer ...


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