Exploring Viral Interference Using Peptides: Molecular Determinants of HIV‐1 Inhibition by a Peptide Derived from Human Pegivirus‐1 Envelope Protein E2

URN to cite this document:: urn:nbn:de:bvb:355-epub-560098
DOI to cite this document:: 10.5283/epub.56009

Hoffmann, Rebecca ; Ruegamer, Tamara ; Schaubächer, Johanna ; Rohrhofer, Anette ; Kirmeß, Peter ; Fiebig, Karen M. ; Schmidt, Barbara

; Eichler, Jutta

License: Creative Commons Attribution Non-commercial No Derivatives 4.0
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Date of publication of this fulltext: 29 Feb 2024 12:25

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Abstract

Co-infection with the human pegivirus 1 (HPgV-1) often has a beneficial effect on disease progression in HIV-1-infected individuals. Several HPgV-1 proteins and peptides, including a 20-mer peptide (P6-2) derived from the N-terminal region of the HPgV-1 surface protein E2, have been associated with this phenomenon, which is referred to as viral interference. We identified the cysteine residues, ...