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Anti-CD19 CAR T cells potently redirected to kill solid tumor cells

Ramos, Joe W. ; Ambrose, Christine ; Su, Lihe ; Wu, Lan ; Dufort, Fay J. ; Sanford, Thomas ; Birt, Alyssa ; Hackel, Benjamin J. ; Hombach, Andreas ; Abken, Hinrich ; Lobb, Roy R. ; Rennert, Paul D.



Abstract

Successful CAR T cell therapy for the treatment of solid tumors requires exemplary CAR T cell expansion, persistence and fitness, and the ability to target tumor antigens safely. Here we address this constellation of critical attributes for successful cellular therapy by using integrated technologies that simplify development and derisk clinical translation. We have developed a CAR-CD19 T cell ...

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