Three dimensional cultivation increases chemo- and radioresistance of colorectal cancer cell lines

URN to cite this document:: urn:nbn:de:bvb:355-epub-560212
DOI to cite this document:: 10.5283/epub.56021

Rishi, Arun ; Koch, Jana ; Mönch, Dina ; Maaß, Annika ; Gromoll, Christian ; Hehr, Thomas ; Leibold, Tobias ; Schlitt, Hans J. ; Dahlke, Marc-H. ; Renner, Philipp

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Date of publication of this fulltext: 29 Feb 2024 12:25

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Abstract

Although 2D cell cultures are commonly used to predict therapy response, it has become clear that 3D cultures may better mimic the in vivo situation and offer the possibility of tailoring translational clinical approaches. Here, we compared the response of 2D and 3D colorectal cancer (CRC) cell lines to irradiation and chemotherapy. Classic 2D cultures and 3D spheroids of CRC cell lines (CaCo2, ...