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De novo Neurosteroidogenesis in Human Microglia: Involvement of the 18 kDa Translocator Protein

Germelli, Lorenzo ; Da Pozzo, Eleonora ; Giacomelli, Chiara ; Tremolanti, Chiara ; Marchetti, Laura ; Wetzel, Christian H. ; Barresi, Elisabetta ; Taliani, Sabrina ; Da Settimo, Federico ; Martini, Claudia ; Costa, Barbara


Neuroactive steroids are potent modulators of microglial functions and are capable of counteracting their excessive reactivity. This action has mainly been ascribed to neuroactive steroids released from other sources, as microglia have been defined unable to produce neurosteroids de novo. Unexpectedly, immortalized murine microglia recently exhibited this de novo biosynthesis; herein, de novo ...


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