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Estrogen deficiency affects tooth formation and gene expression in the odontogenic region of female rats

Küchler, Erika Calvano ; de Lara, Rafaela Mariana ; Omori, Marjorie Ayumi ; Schröder, Agnes ; Teodoro, Vinicius Broska ; Baratto-Filho, Flares ; Léon, Jorge Esquiche ; Proff, Peter ; Madalena, Isabela Ribeiro ; Kirschneck, Christian


Background: There is some evidence that estrogen regulates the expression of several genes in different cells, including dental cells. Therefore, the aim of this study was to investigate the role of estrogen deficiency during tooth development regarding tooth structure morphology and its impact on the expression of odontogenesis-related genes. Methods: A total of 40 female Wistar rats was divided ...


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