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Enhanced activation of blood neutrophils and monocytes in patients with Ethiopian localized cutaneous leishmaniasis in response to Leishmania aethiopica Neutrophil activation in Ethiopian cutaneous leishmaniasis

Chanyalew, Menberework ; Abebe, Markos ; Endale, Birtukan ; Girma, Selfu ; Tasew, Geremew ; Bobosha, Kidist ; Zewide, Martha ; Howe, Rawleigh ; van Zandbergen, Ger ; Ritter, Uwe ; Gadisa, Endalamaw ; Aseffa, Abraham ; Laskay, Tamás


Recent studies suggest an essential role of the innate immune effector cells neutrophils and monocytes in protection or disease progression in the early course of Leishmania infection. In areas endemic for cutaneous leishmaniasis in Ethiopia most individuals are exposed to bites of infected sandflies. Still only a minor ratio of the inhabitants develops symptomatic disease. Neutrophils, followed ...


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