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Filifactor alocis and Tumor Necrosis Factor-Alpha Stimulate Synthesis of Visfatin by Human Macrophages

Nogueira, Andressa Vilas Boas ; Nokhbehsaim, Marjan ; Damanaki, Anna ; Eick, Sigrun ; Kirschneck, Christian ; Schröder, Agnes ; Jantsch, Jonathan ; Deschner, James



Abstract

There is little known about the effect of the periodontopathogen Filifactor alocis on macrophages as key cells of the innate immune defense in the periodontium. Therefore, the aim of the present study was to investigate the effect of F. alocis and additionally of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF alpha) on visfatin and other pro-inflammatory and proteolytic molecules ...

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