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The molecular mechanism of CFTR‐ and secretin‐dependent renal bicarbonate excretion

Berg, Peder ; Svendsen, Samuel L. ; Sorensen, Mads Vaarby ; Schreiber, Rainer ; Kunzelmann, Karl ; Leipziger, Jens


This review summarizes the newly discovered molecular mechanism of secretin-stimulated urine HCO3- excretion and the role of cystic fibrosis transmembrane conductance regulator (CFTR) in renal HCO3- excretion. The secretin receptor is functionally expressed in the basolateral membrane of the HCO(3)(-)secreting beta-intercalated cells of the collecting duct. Here it activates a fast and efficient ...


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