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Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients

Xydia, Maria ; Rahbari, Raheleh ; Ruggiero, Eliana ; Macaulay, Iain ; Tarabichi, Maxime ; Lohmayer, Robert ; Wilkening, Stefan ; Michels, Tillmann ; Brown, Daniel ; Vanuytven, Sebastiaan ; Mastitskaya, Svetlana ; Laidlaw, Sean ; Grabe, Niels ; Pritsch, Maria ; Fronza, Raffaele ; Hexel, Klaus ; Schmitt, Steffen ; Müller-Steinhardt, Michael ; Halama, Niels ; Domschke, Christoph ; Schmidt, Manfred ; von Kalle, Christof ; Schütz, Florian ; Voet, Thierry ; Beckhove, Philipp


Regulatory CD4(+) T cells (Treg) prevent tumor clearance by conventional T cells (Tconv) comprising a major obstacle of cancer immune-surveillance. Hitherto, the mechanisms of Treg repertoire formation in human cancers remain largely unclear. Here, we analyze Treg clonal origin in breast cancer patients using T-Cell Receptor and single-cell transcriptome sequencing. While Treg in peripheral blood ...


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