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SoxD transcription factor deficiency in Schwann cells delays myelination in the developing peripheral nervous system

Ittner, Ella ; Hartwig, Anna C. ; Elsesser, Olga ; Wüst, Hannah M. ; Fröb, Franziska ; Wedel, Miriam ; Schimmel, Margit ; Tamm, Ernst R. ; Wegner, Michael ; Sock, Elisabeth


The three SoxD proteins, Sox5, Sox6 and Sox13, represent closely related transcription factors with important roles during development. In the developing nervous system, SoxD proteins have so far been primarily studied in oligodendroglial cells and in interneurons of brain and spinal cord. In oligodendroglial cells, Sox5 and Sox6 jointly maintain the precursor state, interfere with terminal ...


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