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Dimeric-serotonin bivalent ligands induced gold nanoparticle aggregation for highly sensitive and selective serotonin biosensor

Chavan, Sachin Ganpat ; Yagati, Ajay Kumar ; Kim, Hyun Tae ; Jin, Eunjian ; Park, Sung Ryul ; Patil, Dilip V. ; Lee, Min-Ho



Abstract

Chemically modulating monoamine neurotransmitter serotonin undergoes a physiological reaction of enzyme intermediated peroxidation to reconstruct dimeric self-assembled complex. A standard bivalent ligand approach dimeric serotonin increases structural and functional scaffolding with recognition-binding sites that are fundamentally more friendly than monovalent binding sites. Dimerization ...

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