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Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19

Dugas, Martin ; Grote-Westrick, Tanja ; Merle, Uta ; Fontenay, Michaela ; Kremer, Andreas E. ; Hanses, Frank ; Vollenberg, Richard ; Lorentzen, Eva ; Tiwari-Heckler, Shilpa ; Duchemin, Jérôme ; Ellouze, Syrine ; Vetter, Marcel ; Fürst, Julia ; Schuster, Philipp ; Brix, Tobias ; Denkinger, Claudia M. ; Müller-Tidow, Carsten ; Schmidt, Hartmut ; Tepasse, Phil-Robin ; Kühn, Joachim


Background: The vast majority of COVID-19 patients experience a mild disease. However, a minority suffers from critical disease with substantial morbidity and mortality. Objectives: To identify individuals at risk of critical COVID-19, the relevance of a seroreactivity against seasonal human coronaviruses was analyzed. Methods: We conducted a multi-center non-interventional study comprising 296 ...


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