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Generation and characterization of novel co-stimulatory anti-mouse TNFR2 antibodies

Segués, Aina ; van Duijnhoven, Sander M.J. ; Parade, Marc ; Driessen, Lilian ; Vukovic, Nataša ; Zaiss, Dietmar ; Sijts, Alice J.A.M. ; Berraondo, Pedro ; van Elsas, Andrea



Abstract

Tumor necrosis factor receptor 2 (TNFR2) has gained much research interest in recent years because of its potential pivotal role in autoimmune disease and cancer. However, its function in regulating different immune cells is not well understood. There is a need for well-characterized reagents to selectively modulate TNFR2 function, thereby enabling definition of TNFR2-dependent biology in human ...

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