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GAMIBHEAR: whole-genome haplotype reconstruction from Genome Architecture Mapping data

Markowski, Julia ; Kempfer, Rieke ; Kukalev, Alexander ; Irastorza-Azcarate, Ibai ; Loof, Gesa ; Kehr, Birte ; Pombo, Ana ; Rahmann, Sven ; Schwarz, Roland F ; Ponty, Yann



Abstract

Motivation: Genome Architecture Mapping (GAM) was recently introduced as a digestion- and ligation-free method to detect chromatin conformation. Orthogonal to existing approaches based on chromatin conformation capture (3C), GAM's ability to capture both inter- and intra-chromosomal contacts from low amounts of input data makes it particularly well suited for allele-specific analyses in a ...

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