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Nuclear export of plant pararetrovirus mRNAs involves the TREX complex, two viral proteins and the highly structured 5′ leader region

Kubina, Julie ; Geldreich, Angèle ; Gales, Jón Pol ; Baumberger, Nicolas ; Bouton, Clément ; Ryabova, Lyubov A. ; Grasser, Klaus D. ; Keller, Mario ; Dimitrova, Maria



Abstract

In eukaryotes, the major nuclear export pathway for mature mRNAs uses the dimeric receptor TAP/p15, which is recruited to mRNAs via the multisubunit TREX complex, comprising the THO core and different export adaptors. Viruses that replicate in the nucleus adopt different strategies to hijack cellular export factors and achieve cytoplasmic translation of their mRNAs. No export receptors are known ...

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