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Holdemanella biformis improves glucose tolerance and regulates GLP‐1 signaling in obese mice

Romaní‐Pérez, Marina ; López‐Almela, Inmaculada ; Bullich‐Vilarrubias, Clara ; Rueda‐Ruzafa, Lola ; Gómez Del Pulgar, Eva M. ; Benítez‐Páez, Alfonso ; Liebisch, Gerhard ; Lamas, José Antonio ; Sanz, Yolanda



Abstract

Impaired glucose homeostasis in obesity is mitigated by enhancing the glucoregulatory actions of glucagon-like peptide 1 (GLP-1), and thus, strategies that improve GLP-1 sensitivity and secretion have therapeutic potential for the treatment of type 2 diabetes. This study shows that Holdemanella biformis, isolated from the feces of a metabolically healthy volunteer, ameliorates hyperglycemia, ...

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