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The dysregulation of metabolic pathways and induction of the pentose phosphate pathway in renal ischaemia–reperfusion injury

Scantlebery, Angelique ML ; Tammaro, Alessandra ; Mills, James D ; Rampanelli, Elena ; Kors, Lotte ; Teske, Gwendoline J ; Butter, Loes M ; Liebisch, Gerhard ; Schmitz, Gerd ; Florquin, Sandrine ; Leemans, Jaklien C ; Roelofs, Joris JTH


Lipid accumulation is associated with various forms of acute renal injury; however, the causative factors and pathways underpinning this lipid accumulation have not been thoroughly investigated. In this study, we performed lipidomic profiling of renal tissue following ischaemia-reperfusion injury (IRI). We identified a significant accumulation of cholesterol and specific phospholipids and ...


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