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Airway macrophage-intrinsic TGF-β1 regulates pulmonary immunity during early-life allergen exposure

Branchett, William J. ; Cook, James ; Oliver, Robert A. ; Bruno, Nicoletta ; Walker, Simone A. ; Stölting, Helen ; Mack, Matthias ; O’Garra, Anne ; Saglani, Sejal ; Lloyd, Clare M.



Abstract

Background: Early life represents a major risk window for asthma development. However, the mechanisms controlling the threshold for establishment of allergic airway inflammation in early life are incompletely understood. Airway macrophages (AMs) regulate pulmonary allergic responses and undergo TGF-beta-dependent postnatal development, but the role of AM maturation factors such as TGF-beta in ...

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