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Differential Effects of Prostaglandin D 2 Signaling on Macrophages and Microglia in Murine Coronavirus Encephalomyelitis

Verma, Abhishek Kumar ; Zheng, Jian ; Mack, Matthias ; Ginhoux, Florent ; Perlman, Stanley ; Griffin, Diane E.


Microglia and macrophages initiate and orchestrate the innate immune response to central nervous system (CNS) virus infections. Microglia initiate neurotropic coronavirus clearance from the CNS, but the role of infiltrating macrophages is not well understood. Here, using mice lacking cell-specific expression of DP1, the receptor for prostaglandin D-2 (PGD(2)), we delineate the relative roles of ...


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