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CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin’s lymphoma and tumor-supportive follicular T helper cells

Bunse, Mario ; Pfeilschifter, Janina ; Bluhm, Julia ; Zschummel, Maria ; Joedicke, Jara J. ; Wirges, Anthea ; Stark, Helen ; Kretschmer, Vivien ; Chmielewski, Markus ; Uckert, Wolfgang ; Abken, Hinrich ; Westermann, Jörg ; Rehm, Armin ; Höpken, Uta E.



Abstract

CAR-T cell therapy targeting CD19 demonstrated strong activity against advanced B cell leukemia, however shows less efficacy against lymphoma with nodal dissemination. To target both B cell Non-Hodgkin's lymphoma (B-NHLs) and follicular T helper (Tfh) cells in the tumor microenvironment (TME), we apply here a chimeric antigen receptor (CAR) that recognizes human CXCR5 with high avidity. CXCR5, ...

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