Trevelin, Silvia Cellone ; Sag, Can Martin ; Zhang, Min 
; Alves-Filho, José Carlos ; Cunha, Thiago Mattar ; Santos, Célio Xavier dos ; Sawyer, Greta ; Murray, Thomas ; Brewer, Alison ; Laurindo, Francisco Rafael Martins ; Protti, Andrea ; Lopes, Lucia Rossetti ; Ivetic, Aleksandar ; Cunha, Fernando Queiroz ; Shah, Ajay M.
; Alves-Filho, José Carlos ; Cunha, Thiago Mattar ; Santos, Célio Xavier dos ; Sawyer, Greta ; Murray, Thomas ; Brewer, Alison ; Laurindo, Francisco Rafael Martins ; Protti, Andrea ; Lopes, Lucia Rossetti ; Ivetic, Aleksandar ; Cunha, Fernando Queiroz ; Shah, Ajay M. 
Abstract
Leukocyte Nox2 is recognized to have a fundamental microbicidal function in sepsis but the specific role of Nox2 in endothelial cells (EC) remains poorly elucidated. Here, we tested the hypothesis that endothelial Nox2 participates in the pathogenesis of systemic inflammation and hypotension induced by LPS. LPS was injected intravenously in mice with Tie2-targeted deficiency or transgenic ...
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