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Distinct and Overlapping Roles of Hippo Effectors YAP and TAZ During Human and Mouse Hepatocarcinogenesis

Wang, Haichuan ; Wang, Jingxiao ; Zhang, Shanshan ; Jia, Jiaoyuan ; Liu, Xianqiong ; Zhang, Jie ; Wang, Pan ; Song, Xinhua ; Che, Li ; Liu, Ke ; Ribback, Silvia ; Cigliano, Antonio ; Evert, Matthias ; Wu, Hong ; Calvisi, Diego F. ; Zeng, Yong ; Chen, Xin



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BACKGROUND & AIMS: Yes-associated protein (YAP) and its paralog transcriptional co-activator with post synaptic density protein, drosophila disc large tumor suppressor and zonula occludens-1-binding motif (TAZ) are 2 co-activators downstream of Hippo tumor-suppressor cascade. Both have been implicated in the development of hepatocellular carcinoma (HCC). However, whether YAP and TAZ have distinct ...

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