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TRAIL-receptor 2—a novel negative regulator of p53

Willms, Anna ; Schupp, Hella ; Poelker, Michelle ; Adawy, Alshaimaa ; Debus, Jan Frederik ; Hartwig, Torsten ; Krichel, Tim ; Fritsch, Jürgen ; Singh, Steven ; Walczak, Henning ; von Karstedt, Silvia ; Schäfer, Heiner ; Trauzold, Anna



Abstract

TNF-related apoptosis-inducing ligand (TRAIL) receptor 2 (TRAIL-R2) can induce apoptosis in cancer cells upon crosslinking by TRAIL. However, TRAIL-R2 is highly expressed by many cancers suggesting pro-tumor functions. Indeed, TRAIL/TRAIL-R2 also activate pro-inflammatory pathways enhancing tumor cell invasion, migration, and proliferation. In addition, nuclear TRAIL-R2 (nTRAIL-R2) promotes ...

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