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Skin sodium is increased in male patients with multiple sclerosis and related animal models

Huhn, Konstantin ; Linz, Peter ; Pemsel, Franziska ; Michalke, Bernhard ; Seyferth, Stefan ; Kopp, Christoph ; Chaudri, Mohammad Anwar ; Rothhammer, Veit ; Dörfler, Arnd ; Uder, Michael ; Nagel, Armin M. ; Müller, Dominik N. ; Waschbisch, Anne ; Lee, De-Hyung ; Bäuerle, Tobias ; Linker, Ralf A. ; Haase, Stefanie




Abstract

Novel MRI techniques allow a noninvasive quantification of tissue sodium and reveal the skin as a prominent compartment of sodium storage in health and disease. Since multiple sclerosis (MS) immuno-pathology is initiated in the periphery and increased sodium con-centrations induce proinflammatory immune cells, the skin represents a promising compartment linking high sodium concentrations and MS ...

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