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The Prognostic Value of FGFR3 Expression in Patients with T1 Non-Muscle Invasive Bladder Cancer

Sikic, Danijel ; Taubert, Helge ; Breyer, Johannes ; Eckstein, Markus ; Weyerer, Veronika ; Keck, Bastian ; Kubon, Jennifer ; Otto, Wolfgang ; Worst, Thomas S ; Kriegmair, Maximilian C ; Erben, Philipp ; Hartmann, Arndt ; Wullich, Bernd ; Wirtz, Ralph M ; Wach, Sven



Abstract

Purpose: Fibroblast growth factor receptor 3 (FGFR3) alterations are frequent in non-muscle-invasive bladder cancer (NMIBC), although current data regarding the prognostic and therapeutic relevance are inconsistent. We analyzed the prognostic role of FGFR3 mRNA expression in stage T1 NMIBC. Patients and Methods: The mRNA expression of FGFR3 and cyclin-dependent kinase inhibitor 2A (CDKN2A) was ...

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