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L-type amino acid transporter (LAT) 1 expression in 18F-FET-negative gliomas

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Vettermann, Franziska J. ; Diekmann, Caroline ; Weidner, Lorraine ; Unterrainer, Marcus ; Suchorska, Bogdana ; Ruf, Viktoria ; Dorostkar, Mario ; Wenter, Vera ; Herms, Jochen ; Tonn, Jörg-Christian ; Bartenstein, Peter ; Riemenschneider, Markus J. ; Albert, Nathalie L.
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Date of publication of this fulltext: 29 Feb 2024 12:28


Background O-(2-[18F]-fluoroethyl)-L-tyrosine (18F-FET) is a highly sensitive PET tracer for glioma imaging, and its uptake is suggested to be driven by an overexpression of the L-type amino-acid transporter 1 (LAT1). However, 30% of low- and 5% of high-grade gliomas do not present enhanced 18F-FET uptake at primary diagnosis (“18F-FET-negative gliomas”) and the pathophysiologic basis for this ...


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