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Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity

Hanna, Bola S. ; Llaó-Cid, Laura ; Iskar, Murat ; Roessner, Philipp M. ; Klett, Lara C. ; Wong, John K.L. ; Paul, Yashna ; Ioannou, Nikolaos ; Öztürk, Selcen ; Mack, Norman ; Kalter, Verena ; Colomer, Dolors ; Campo, Elías ; Bloehdorn, Johannes ; Stilgenbauer, Stephan ; Dietrich, Sascha ; Schmidt, Manfred ; Gabriel, Richard ; Rippe, Karsten ; Feuerer, Markus ; Ramsay, Alan G. ; Lichter, Peter ; Zapatka, Marc ; Seiffert, Martina


T cell exhaustion limits anti-tumor immunity and responses to immunotherapy, Here, we explored the microenvironmental signals regulating T cell exhaustion using a model of chronic lymphocytic leukemia (CLL). Single-cell analyses identified a subset of PD-1(hi), functionally impaired CD8(+) T cells that accumulated in secondary lymphoid organs during disease progression and a functionally ...


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