Go to content
UR Home

Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity

Hanna, Bola S. ; Llaó-Cid, Laura ; Iskar, Murat ; Roessner, Philipp M. ; Klett, Lara C. ; Wong, John K.L. ; Paul, Yashna ; Ioannou, Nikolaos ; Öztürk, Selcen ; Mack, Norman ; Kalter, Verena ; Colomer, Dolors ; Campo, Elías ; Bloehdorn, Johannes ; Stilgenbauer, Stephan ; Dietrich, Sascha ; Schmidt, Manfred ; Gabriel, Richard ; Rippe, Karsten ; Feuerer, Markus ; Ramsay, Alan G. ; Lichter, Peter ; Zapatka, Marc ; Seiffert, Martina



Abstract

T cell exhaustion limits anti-tumor immunity and responses to immunotherapy, Here, we explored the microenvironmental signals regulating T cell exhaustion using a model of chronic lymphocytic leukemia (CLL). Single-cell analyses identified a subset of PD-1(hi), functionally impaired CD8(+) T cells that accumulated in secondary lymphoid organs during disease progression and a functionally ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons