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Targeting Cancer Metabolism Breaks Radioresistance by Impairing the Stress Response

Schwab, Melissa ; Thunborg, Katharina ; Azimzadeh, Omid ; von Toerne, Christine ; Werner, Caroline ; Shevtsov, Maxim ; Di Genio, Tommaso ; Zdralevic, Masa ; Pouyssegur, Jacques ; Renner, Kathrin ; Kreutz, Marina ; Multhoff, Gabriele


Simple Summary Ionizing radiation is a major pillar in the therapy of solid tumors. However, normal tissue toxicities and radioresistance of tumor cells can limit the therapeutic success of radiotherapy. In this study, we investigated the coregulation of the cancer metabolism and the heat shock response with respect to radioresistance. Our results indicate that an inhibition of lactate ...


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