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Brown adipose tissue monocytes support tissue expansion

Gallerand, Alexandre ; Stunault, Marion I. ; Merlin, Johanna ; Luehmann, Hannah P. ; Sultan, Deborah H. ; Firulyova, Maria M. ; Magnone, Virginie ; Khedher, Narges ; Jalil, Antoine ; Dolfi, Bastien ; Castiglione, Alexia ; Dumont, Adelie ; Ayrault, Marion ; Vaillant, Nathalie ; Gilleron, Jérôme ; Barbry, Pascal ; Dombrowicz, David ; Mack, Matthias ; Masson, David ; Bertero, Thomas ; Becher, Burkhard ; Williams, Jesse W. ; Zaitsev, Konstantin ; Liu, Yongjian ; Guinamard, Rodolphe R. ; Yvan-Charvet, Laurent ; Ivanov, Stoyan



Abstract

Monocytes are part of the mononuclear phagocytic system. Monocytes play a central role during inflammatory conditions and a better understanding of their dynamics might open therapeutic opportunities. In the present study, we focused on the characterization and impact of monocytes on brown adipose tissue (BAT) functions during tissue remodeling. Single-cell RNA sequencing analysis of BAT immune ...

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