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Small Extracellular Vesicles from Head and Neck Squamous Cell Carcinoma Cells Carry a Proteomic Signature for Tumor Hypoxia

Głuszko, Alicja ; Szczepański, Mirosław J. ; Whiteside, Theresa L. ; Reichert, Torsten E. ; Siewiera, Jacek ; Ludwig, Nils



Abstract

Simple Summary Tissue hypoxia is a hallmark of head and neck squamous cell carcinoma (HNSCC) and is considered to drive tumor progression and resistance to anti-cancer therapies. The aim of our study was to characterize the influence of hypoxic environments on the release and proteomic cargo composition of small extracellular vesicles (sEVs). We demonstrated in three HNSCC cell lines that sEV ...

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