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Chronic Toxoplasma gondii infection enhances susceptibility to colitis

Saraav, Iti ; Cervantes-Barragan, Luisa ; Olias, Philipp ; Fu, Yong ; Wang, Qiuling ; Wang, Leran ; Wang, Yi ; Mack, Matthias ; Baldridge, Megan T. ; Stappenbeck, Thaddeus ; Colonna, Marco ; Sibley, L. David



Abstract

Oral infection with Toxoplasma gondii results in dysbiosis and enteritis, both of which revert to normal during chronic infection. However, whether infection leaves a lasting impact on mucosal responses remains uncertain. Here we examined the effect of the chemical irritant dextran sodium sulfate (DSS) on intestinal damage and wound healing in chronically infected mice. Our findings indicate that ...

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