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Inducible and reversible inhibition of miRNA-mediated gene repression in vivo

King, Bryan ; La Rocca, Gaspare ; Shui, Bing ; Li, Xiaoyi ; Zhang, Minsi ; Akat, Kemal M ; Ogrodowski, Paul ; Mastroleo, Chiara ; Chen, Kevin ; Cavalieri, Vincenzo ; Ma, Yilun ; Anelli, Viviana ; Betel, Doron ; Vidigal, Joana ; Tuschl, Thomas ; Meister, Gunter ; Thompson, Craig B ; Lindsten, Tullia ; Haigis, Kevin ; Ventura, Andrea



Abstract

Although virtually all gene networks are predicted to be controlled by miRNAs, the contribution of this important layer of gene regulation to tissue homeostasis in adult animals remains unclear. Gain and loss-of-function experiments have provided key insights into the specific function of individual miRNAs, but effective genetic tools to study the functional consequences of global inhibition of ...

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