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Biologicals in childhood severe asthma: the European PERMEABLE survey on the status quo

Santos-Valente, Elisangela ; Buntrock-Döpke, Heike ; Abou Taam, Rola ; Arasi, Stefania ; Bakirtas, Arzu ; Lozano Blasco, Jaime ; Bønnelykke, Klaus ; Craiu, Mihai ; Cutrera, Renato ; Deschildre, Antoine ; Elnazir, Basil ; Fleming, Louise ; Frey, Urs ; Gappa, Monika ; Nieto García, Antonio ; Skamstrup Hansen, Kirsten ; Hanssens, Laurence ; Jahnz-Rozyk, Karina ; Jesenak, Milos ; Kerzel, Sebastian ; Kopp, Matthias V. ; Koppelman, Gerard H. ; Krivec, Uros ; MacLeod, Kenneth A. ; Mäkelä, Mika ; Melén, Erik ; Mezei, Györgyi ; Moeller, Alexander ; Moreira, Andre ; Pohunek, Petr ; Minić, Predrag ; Rutjes, Niels W.P. ; Sammut, Patrick ; Schwerk, Nicolaus ; Szépfalusi, Zsolt ; Turkalj, Mirjana ; Tzotcheva, Iren ; Ulmeanu, Alexandru ; Verhulst, Stijn ; Xepapadaki, Paraskevi ; Niggel, Jakob ; Vijverberg, Susanne ; Maitland-van der Zee, Anke H. ; Potočnik, Uroš ; Reinartz, Susanne M. ; van Drunen, Cornelis M. ; Kabesch, Michael



Abstract

Introduction Severe asthma is a rare disease in children, for which three biologicals, anti-immunoglobulin E, anti-interleukin-5 and anti-IL4RA antibodies, are available in European countries. While global guidelines exist on who should receive biologicals, knowledge is lacking on how those guidelines are implemented in real life and which unmet needs exist in the field. In this survey, we aimed ...

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