Go to content
UR Home

FYCO1 Regulates Cardiomyocyte Autophagy and Prevents Heart Failure Due to Pressure Overload In Vivo

Kuhn, Christian ; Menke, Maja ; Senger, Frauke ; Mack, Claudia ; Dierck, Franziska ; Hille, Susanne ; Schmidt, Inga ; Brunke, Gabriele ; Bünger, Pia ; Schmiedel, Nesrin ; Will, Rainer ; Sossalla, Samuel ; Frank, Derk ; Eschenhagen, Thomas ; Carrier, Lucie ; Lüllmann-Rauch, Renate ; Rangrez, Ashraf Yusuf ; Frey, Norbert


Autophagy is a cellular degradation process that has been implicated in diverse disease processes. The authors provide evidence that FYCO1, a component of the autophagic machinery, is essential for adaptation to cardiac stress. Although the absence of FYCO1 does not affect basal autophagy in isolated cardiomyocytes, it abolishes induction of autophagy after glucose deprivation. Likewise, ...


Owner only: item control page
  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons