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FYCO1 Regulates Cardiomyocyte Autophagy and Prevents Heart Failure Due to Pressure Overload In Vivo

Kuhn, Christian ; Menke, Maja ; Senger, Frauke ; Mack, Claudia ; Dierck, Franziska ; Hille, Susanne ; Schmidt, Inga ; Brunke, Gabriele ; Bünger, Pia ; Schmiedel, Nesrin ; Will, Rainer ; Sossalla, Samuel ; Frank, Derk ; Eschenhagen, Thomas ; Carrier, Lucie ; Lüllmann-Rauch, Renate ; Rangrez, Ashraf Yusuf ; Frey, Norbert



Abstract

Autophagy is a cellular degradation process that has been implicated in diverse disease processes. The authors provide evidence that FYCO1, a component of the autophagic machinery, is essential for adaptation to cardiac stress. Although the absence of FYCO1 does not affect basal autophagy in isolated cardiomyocytes, it abolishes induction of autophagy after glucose deprivation. Likewise, ...

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